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Knight, Jonathan

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Chorionic Gonadotropin (HCG)

Commonly Oral Chorionic Gonadotropin for used for a variety of theriogenology conditions in cattle, horses, dogs, cats, swine, sheep, goats and other species. Chorionic gonadotropin hCG mimics the effects of luteinizing hormone LH. In males, hCG stimulates the differentiation of testicular interstitial Leydig cells and produces androgens. Hormonal treatment of cryptorchidism with hCG is controversial in humans and domestic animals. In females, hCG is primarily used as an ovulation-inducing agent extra-label. In the bitch, administration of hCG induces estrogen secretion during anestrus and can, therefore, be used to identify spayed bitches with ovarian remnants. After IM injection, peak plasma levels occur in about 6 Oral Chorionic Gonadotropin. The initial elimination half-life in humans is about 11 hours, and the terminal half-life is approximately Oral Chorionic Gonadotropin hours. No labeled contraindications for veterinary patients were noted, but the above human contraindications should be used as guidelines. Antibody production to this hormone has been reported after repetitive use; however, despite this effect, pharmacologic activity Oral Chorionic Gonadotropin of ovulation is expected to remain unaltered. Potentially, hypersensitivity reactions are possible with this agent. Anaphylactic reactions are rare, and several practitioners have anecdotally reported mares showing transient hives and respiratory distress immediately following hCG administration. Problems associated with using hCG in dogs for estrus induction include unpredictability of response, potential for allergic reactions, and premature luteal failure. In humans, the FDA categorizes this drug as category X for use during pregnancy.

Luteal phase support for assisted reproduction

Human chorionic gonadotropin hCG is a hormone for the maternal recognition of pregnancy produced by trophoblast cells that are surrounding a growing embryo syncytiotrophoblast initiallywhich eventually forms the placenta after implantation. Some cancerous tumors produce this hormone; therefore, elevated levels measured when the patient is not pregnant may lead to a cancer diagnosis and, if high enough, paraneoplastic syndromeshowever, it is not known whether this production is a contributing cause, or an effect of carcinogenesis. The pituitary analog of hCG, known as luteinizing hormone LHis produced in the pituitary gland of males and females of all ages. Various endogenous forms of hCG exist. The measurement of these diverse forms is used in the diagnosis of pregnancy and a variety of disease states. As of December 6, [update]the United States Food and Drug Administration has prohibited the sale of " homeopathic " and over-the-counter hCG diet products and declared them fraudulent and illegal. Beta-hCG is initially secreted by the syncytiotrophoblast. Human chorionic gonadotropin is a glycoprotein composed of amino acids with a molecular mass of The two subunits create a small hydrophobic core surrounded by a high surface area-to-volume ratio: 2. The vast majority of the outer amino acids are hydrophilic. Human chorionic gonadotropin interacts with the LHCG receptor of the ovary and promotes the maintenance of the corpus luteum for the maternal recognition of pregnancy at the beginning of pregnancy. This allows Oral Chorionic Gonadotropin corpus luteum to secrete the hormone progesterone during the first trimester. Progesterone Oral Chorionic Gonadotropin the Oral Chorionic Gonadotropin with a thick lining of blood vessels and capillaries so that it can sustain the growing fetus. It has been hypothesized that hCG may be a placental link for the Oral Chorionic Gonadotropin of local maternal immunotolerance. These results suggest that hCG may be a link in the development of peritrophoblastic immune tolerance, Oral Chorionic Gonadotropin may facilitate the trophoblast invasion, which is known to expedite fetal development in the endometrium.

Human chorionic gonadotropin

Background: Growing evidence supports the existence of immune-surveillance mechanisms in ovarian tumour patients, including autoantibodies to tumour associated and tumour specific antigens, tumour growth factors. It is believed that hCG plays a role of an autocrine growth factor for tumor cells. Here we have demonstrated that sera of patients with ovarian cyst contain naturally-occurring autoantibodies, predominantly of IgG2 isotype, that bind to hCG and its subunits with high affinity. The same type of ELISA with necessary modifications was used for further investigation of subclass usage and assessment of binding affinity of the detected autoantibodies. These autoantibodies predominantly belonged to the IgG2 subclass and were characterized by the high binding affinity. It is plausible that they cross- bind to sugar side chains of hCG and its subunits. The overwhelming majority of these autoantibodies belong to the IgG2 isotype thus indicating that they might be directed against carbohydrate antigens within highly glycosylated hCG. Prevalence of high affinity naturally occurring IgG2 antibodies against human chorionic gonadotropin and its subunits in patients with ovarian cyst Porakishvili, N. Prevalence of high affinity naturally occurring IgG2 antibodies against human chorionic gonadotropin and its subunits in patients with ovarian cyst. Expression patterns of CD in the lymph nodes of patients with chronic lymphocytic leukaemia Edwards, K. Expression patterns of CD in the lymph nodes of patients with chronic lymphocytic leukaemia.